Description

n-T-Butyl-3-(4-(m-Trifluoromethylphenyl)Piperazinyl)Azetidine is a high-purity, advanced pharmaceutical intermediate featuring a unique piperazinyl-azetidine scaffold. This compound matters for its critical role as a key building block in the synthesis of novel bioactive molecules, particularly in central nervous system (CNS) and receptor-targeted drug discovery. Pharmaceutical R&D teams and fine chemical manufacturers need this specialized intermediate to develop next-generation therapeutics, leveraging its structural complexity to create potent and selective active pharmaceutical ingredients (APIs).

Application

• Primary building block for the synthesis of novel psychoactive pharmaceuticals and CNS-targeting drug candidates.
• Key intermediate in medicinal chemistry research for developing receptor modulators, including potential antipsychotics and antidepressants.
• Precursor for creating complex molecules in high-throughput screening libraries for drug discovery programs.
• Used in the research and development of ligands for various neurological and GPCR (G-protein-coupled receptor) targets.
• Essential material for process chemistry and scale-up synthesis of candidate drugs in preclinical and clinical development phases.
• Intermediate for producing reference standards and metabolites in pharmacological studies and analytical method development.

Basic Information

Product Name	n-T-Butyl-3-(4-(m-Trifluoromethylphenyl)Piperazinyl)Azetidine
CAS No.	223381-91-7
Molecular Formula	C18H26F3N3
Molecular Weight	341.42 g/mol
Synonyms	1-(1,1-Dimethylethyl)-3-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]azetidine; 1-tert-Butyl-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)azetidine; 3-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]-1-(1,1-dimethylethyl)azetidine; n-tert-Butyl-3-(4-(m-trifluoromethylphenyl)piperazinyl)azetidine; CAS 223381-91-7; T-Butyl-3-(4-(m-Trifluoromethylphenyl)Piperazinyl)Azetidine
EINECS	Contact for details

Quality Control

Our n-T-Butyl-3-(4-(m-Trifluoromethylphenyl)Piperazinyl)Azetidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our quality commitment supports cGMP compliance for pharmaceutical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.