Description

1-Piperazinecarboxaldehyde,4-(2-Mercaptoethyl)-(9Ci) is a specialized heterocyclic building block containing both aldehyde and thiol functional groups. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients. The compound's reactivity profile allows for selective modifications, enabling the construction of targeted molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas requiring thiol- or aldehyde-mediated conjugation.
• Ligand Synthesis: Used in the preparation of chelating agents and ligands for catalysis or metal complexation studies.
• Peptidomimetic Research: Serves as a scaffold for creating constrained peptide analogs and protease inhibitors due to its piperazine core.
• Bioconjugation Chemistry: The thiol group enables site-specific protein/antibody labeling and linker formation in ADC (Antibody-Drug Conjugate) development.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents with specific mode-of-action targets.
• Material Science: Potential monomer or cross-linker in the synthesis of functional polymers and resins.

Basic Information

Product Name	1-Piperazinecarboxaldehyde,4-(2-Mercaptoethyl)-(9Ci)
CAS No.	222857-05-8
Molecular Formula	C7H14N2OS
Molecular Weight	174.26 g/mol
Synonyms	4-(2-Mercaptoethyl)piperazine-1-carbaldehyde; 1-Piperazinecarboxaldehyde, 4-(2-mercaptoethyl)-; 4-(2-Sulfanylethyl)piperazine-1-carbaldehyde; 2-(4-Formylpiperazin-1-yl)ethanethiol; 4-(2-Mercaptoethyl)-1-piperazinecarboxaldehyde; Piperazine derivative CAS 222857-05-8
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxaldehyde,4-(2-Mercaptoethyl)-(9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, impurity profile, and physical characteristics. We support cGMP-compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. Due to its sensitivity to oxidation and moisture, the container should be opened only under controlled conditions and resealed immediately after use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.