Description

7H-Pyrazolo[4,3-d]pyrimidin-7-one, 3-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,4-dihydro- is a complex heterocyclic compound featuring a fused pyrazolo-pyrimidinone core linked to a functionalized pyrrolidine moiety. This molecule is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated building block or potential intermediate for novel therapeutics. Its unique structure, containing multiple chiral centers and a mercaptomethyl group, makes it a valuable scaffold for medicinal chemists targeting enzyme inhibition and receptor modulation. Key industries requiring this high-purity specialty chemical include pharmaceutical R&D, biotechnology, and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting purine-binding enzymes.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Probe Development: Acts as a key component in developing tool compounds for studying biological pathways related to its heterocyclic core.
• Nucleoside/Nucleotide Analog Synthesis: The structural features make it suitable for creating modified nucleoside analogs with potential antiviral or anticancer activity.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a chiral, polyfunctionalized intermediate with specific stereochemistry.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and manufacturers specializing in custom synthesis and process development.

Basic Information

Product Name	7H-Pyrazolo[4,3-d]pyrimidin-7-one, 3-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,4-dihydro-
CAS No.	222631-81-4
Molecular Formula	C12H15N5O3S
Molecular Weight	309.35 g/mol
Synonyms	3-[(2S,3S,4R,5S)-3,4-Dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; (2S,3S,4R,5S)-2-[1,4-Dihydro-7-oxo-7H-pyrazolo[4,3-d]pyrimidin-3-yl]-5-(mercaptomethyl)pyrrolidine-3,4-diol; Mercaptopurinol nucleoside analog; Pyrazolopyrimidinone pyrrolidine derivative; SH-Containing pyrazolo[4,3-d]pyrimidine
EINECS	Contact for details

Quality Control

This high-value specialty chemical is produced under strict quality control protocols to ensure batch-to-batch consistency and integrity. Our rigorous testing includes identity confirmation, purity assessment, and chiral purity verification using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, impurities, and other critical parameters. We adhere to cGMP principles where applicable to support its use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity, keep the container tightly sealed when not in use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.