Description

7H-Pyrazolo4,3-Dpyrimidin-7-One, 3-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,4-Dihydro- is a high-purity, complex heterocyclic compound with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of novel therapeutic agents, particularly in oncology and antiviral research. This product is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of purine nucleoside analogue-based active pharmaceutical ingredients (APIs).
• Oncology Research: Used in the development of targeted cancer therapies that interfere with nucleotide metabolism and DNA synthesis in rapidly dividing cells.
• Antiviral Drug Development: Serves as a precursor for novel antiviral compounds, particularly those targeting viral polymerases and replication mechanisms.
• Biochemical Research: Utilized as a reference standard or probe in enzymatic studies and biochemical assays to investigate nucleotide-related pathways.
• Preclinical Development: Employed in the scale-up synthesis and process optimization for new chemical entities (NCEs) before clinical trials.
• Custom Synthesis: Starting material for the custom manufacturing of specialized, high-value compounds for client-specific research programs.

Basic Information

Item	Detail
Product Name	7H-Pyrazolo4,3-Dpyrimidin-7-One, 3-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,4-Dihydro-
CAS No.	222631-80-3
Molecular Formula	C12H15N5O3
Molecular Weight	277.28 g/mol
Synonyms	3-((2S,3S,4R,5R)-3,4-Dihydroxy-5-methylpyrrolidin-2-yl)-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; (2S,3S,4R,5R)-2-(1,4-Dihydro-7-oxo-7H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-methylpyrrolidine-3,4-diol; A purine nucleoside analogue intermediate; Pyrazolopyrimidinone pyrrolidinol derivative; Stereoisomeric pyrazolo[4,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 7H-Pyrazolo4,3-Dpyrimidin-7-One intermediate is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR for structural confirmation, and residual solvent analysis to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided for each lot, supporting compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.