Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]-1,5-dihydro- is a complex heterocyclic compound featuring a fused pyrrolopyrimidinone core linked to a substituted pyrrolidine moiety. This molecule is of significant interest in advanced pharmaceutical research and development due to its intricate stereochemistry and potential as a key synthetic intermediate or pharmacophore. It is primarily sought by research chemists and process development scientists in the pharmaceutical and biotechnology sectors. The compound with CAS number 222631-64-3 represents a high-value building block for creating novel therapeutic agents.

Application

This specialized chemical serves as a critical intermediate in several high-tech applications:

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analogs and antiviral or anticancer drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Biochemical Tool Compound: Potential use as a probe or inhibitor in enzymatic studies targeting purine metabolism pathways.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes under GMP conditions.
• Academic Research: Employed in universities and research institutes for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Item	Detail
Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]-1,5-dihydro-
CAS No.	222631-64-3
Molecular Formula	C12H16N4O3
Molecular Weight	264.28 g/mol
Synonyms	7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-methylpyrrolidin-2-yl)-4H-pyrrolo[3,2-d]pyrimidin-4-one; (2S,3S,4R,5R)-2-(4-Oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylpyrrolidine-3,4-diol; 7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-methyl-2-pyrrolidinyl-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; A potential nucleoside analog intermediate.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development use, with specifications typically focusing on identity and purity. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, chiral purity, and impurity profiles. For advanced applications, we can discuss custom synthesis and control strategies aligned with GMP or ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0%
Chiral Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.