Description

(3S,4S)-4-(4-(Benzyloxy)Phenyl)-3-((S)-1,2-Dihydroxyethyl)-1-(4-Fluorophenyl)Azetidin-2-One is a high-purity, chiral azetidin-2-one derivative, a critical advanced pharmaceutical intermediate (API) in modern synthetic chemistry. Its precise stereochemistry makes it an essential building block for the development of novel, potent therapeutic agents, particularly in the field of enzyme inhibition. This compound is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules. The CAS number for this compound is 221349-56-0.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly those targeting enzymatic pathways.
• β-Lactam Research: Serves as a sophisticated precursor for novel non-antibiotic β-lactam structures with potential applications beyond traditional antimicrobials.
• Chiral Catalyst & Ligand Development: The complex stereocenters provide a valuable scaffold for developing new asymmetric catalysts and ligands for organic synthesis.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for complex active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable tool for universities and research institutes exploring new chemical entities and synthetic methodologies in organic and medicinal chemistry.

Basic Information

Product Name	(3S,4S)-4-(4-(Benzyloxy)Phenyl)-3-((S)-1,2-Dihydroxyethyl)-1-(4-Fluorophenyl)Azetidin-2-One
CAS No.	221349-56-0
Molecular Formula	C24H22FNO4
Molecular Weight	407.44 g/mol
Synonyms	(3S,4S)-4-[4-(Benzyloxy)phenyl]-3-[(1S)-1,2-dihydroxyethyl]-1-(4-fluorophenyl)azetidin-2-one; (3S-cis)-4-[4-(Phenylmethoxy)phenyl]-3-[(1S)-1,2-dihydroxyethyl]-1-(4-fluorophenyl)-2-azetidinone; 4-(4-Benzyloxyphenyl)-3-((S)-1,2-dihydroxyethyl)-1-(4-fluorophenyl)azetidin-2-one (3S,4S)-; Azetidin-2-one, 4-[4-(benzyloxy)phenyl]-3-[(1S)-1,2-dihydroxyethyl]-1-(4-fluorophenyl)-, (3S,4S)-; Benzyloxy-Fluoro Azetidinone Derivative; Chiral Azetidinone Intermediate; API Intermediate 221349-56-0
EINECS	Contact for details

Quality Control

Our (3S,4S)-4-(4-(Benzyloxy)Phenyl)-3-((S)-1,2-Dihydroxyethyl)-1-(4-Fluorophenyl)Azetidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.