Description

1,4-Dioxaspiro[4.4]Nonane-2-Carboxaldehyde,3-Methyl-,(2S,3R)-(9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. Its value lies in its rigid spirocyclic acetal structure and aldehyde functionality, which serve as a key precursor for constructing complex molecular architectures with precise stereocontrol. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where specific three-dimensional shape is crucial for biological activity. CAS number 221315-27-1.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where the specific (2S,3R) configuration can enhance efficacy and reduce environmental impact.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical and Flavor/Fragrance Intermediate: Employed in the synthesis of complex, high-value odorants and flavoring agents that require specific stereochemistry.
• Academic and Process R&D: A valuable tool for methodological development in organic synthesis, enabling studies on stereoselective reactions and natural product synthesis.

Basic Information

Item	Detail
Product Name	1,4-Dioxaspiro[4.4]Nonane-2-Carboxaldehyde,3-Methyl-,(2S,3R)-(9Ci)
CAS No.	221315-27-1
Molecular Formula	C10H16O3
Molecular Weight	184.23 g/mol
Synonyms	(2S,3R)-3-Methyl-1,4-dioxaspiro[4.4]nonane-2-carboxaldehyde; (2S,3R)-3-Methyl-1,4-dioxaspiro[4.4]nonane-2-carbaldehyde; (2S,3R)-3-Methyl-2-formyl-1,4-dioxaspiro[4.4]nonane; 3-Methyl-1,4-dioxaspiro[4.4]nonane-2-carboxaldehyde, (2S,3R)-; Chiral spiroacetal aldehyde; (2S,3R)-Methyl dioxaspiro nonane carboxaldehyde
EINECS	Contact for details

Quality Control

Our 1,4-Dioxaspiro[4.4]Nonane-2-Carboxaldehyde,3-Methyl-,(2S,3R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2S,3R)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.