Description

5-Bromopyrazine-2-Carbonitrile is a versatile heterocyclic building block of significant importance in modern organic synthesis. Its value lies in the strategic combination of a bromine substituent and a nitrile group on a pyrazine core, enabling a wide range of cross-coupling and functional group transformations. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Serves as a critical building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Used in the creation of organic electronic materials, ligands for catalysis, and advanced polymers due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations to introduce complex substituents.
• Nitrile Functionalization: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles and triazoles.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.

Basic Information

Product Name	5-Bromopyrazine-2-Carbonitrile
CAS No.	221295-04-1
Molecular Formula	C5H2BrN3
Molecular Weight	183.99 g/mol
Synonyms	2-Bromo-5-cyanopyrazine; 5-Bromo-2-cyanopyrazine; 2-Cyano-5-bromopyrazine; Pyrazine-2-carbonitrile, 5-bromo-; 5-Bromopyrazinecarbonitrile; 221295-04-1; 5-Bromo-2-pyrazinecarbonitrile
EINECS	Contact for details

Quality Control

Our 5-Bromopyrazine-2-Carbonitrile is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality systems are designed to meet the stringent requirements of cGMP for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.