Description

3-Fluoro-4-(4-Methylpiperazin-1-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate featuring a unique aniline core substituted with both fluorine and a methylpiperazine group. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing novel therapeutic agents, where its specific structure enables precise modulation of biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drugs, especially kinase inhibitors and receptor antagonists.
• Oncology Research: Used in the development of targeted cancer therapies due to its potential to enhance drug selectivity and efficacy.
• CNS Drug Discovery: Serves as a precursor in creating compounds for treating neurological and psychiatric disorders.
• Agrochemical Synthesis: Employed in the research and development of advanced pesticides and herbicides.
• Material Science: Utilized in the synthesis of specialty polymers and functional materials requiring specific aniline derivatives.
• Chemical Research & Development: Acts as a versatile reagent for exploring new synthetic pathways and creating novel chemical entities in academic and industrial labs.

Basic Information

Product Name	3-Fluoro-4-(4-Methylpiperazin-1-Yl)Aniline
CAS No.	221198-99-8
Molecular Formula	C11H16FN3
Molecular Weight	209.27 g/mol
Synonyms	3-Fluoro-4-(4-methyl-1-piperazinyl)aniline; 1-(2-Fluoro-4-aminophenyl)-4-methylpiperazine; 4-Amino-2-fluoro-1-(4-methylpiperazin-1-yl)benzene; Benzenamine, 3-fluoro-4-(4-methyl-1-piperazinyl)-; 221198-99-8; 3-Fluoro-4-(4-methylpiperazino)aniline; 2-Fluoro-4-amino-N-methylpiperazine
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(4-Methylpiperazin-1-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in its original packaging to minimize exposure to air and moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.