Description

2-Piperazinemethanethiol,-α-,1,4-Trimethyl-,(-α-R,2S)-Rel-(9Ci) is a specialized chiral piperazine derivative featuring a thiol functional group, making it a valuable building block in advanced organic synthesis. Its precise stereochemistry and reactive thiol moiety are critical for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily utilized by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated sulfur-containing heterocycles.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, including potential CNS drugs and enzyme inhibitors.
• Ligand Synthesis: Used in the preparation of specialized ligands for asymmetric catalysis and metal complexation studies.
• Peptidomimetics Research: Acts as a constrained scaffold for designing and synthesizing peptide mimics to modulate biological activity.
• Chemical Biology Probes: Employed in the creation of molecular probes to study enzyme mechanisms and protein interactions involving thiol chemistry.
• Advanced Material Science: Investigated as a monomer or functional additive in the synthesis of polymers with specific chiral or sulfur-based properties.

Basic Information

Product Name	2-Piperazinemethanethiol,-α-,1,4-Trimethyl-,(-α-R,2S)-Rel-(9Ci)
CAS No.	221056-46-8
Molecular Formula	C8H18N2S
Molecular Weight	174.31 g/mol
Synonyms	(αR,2S)-α,1,4-Trimethyl-2-piperazinemethanethiol; (rel)-(αR,2S)-α,1,4-Trimethyl-2-piperazinemethanethiol; 2-Piperazinemethanethiol, α,1,4-trimethyl-, (αR,2S)-rel-; (2S,αR)-rel-α,1,4-Trimethyl-2-piperazinemethanethiol; 1,4-Dimethyl-2-((R)-1-methyl-2-mercaptoethyl)piperazine; Chiral Trimethylpiperazinemethanethiol
EINECS	Contact for details

Quality Control

Every batch of 2-Piperazinemethanethiol,-α-,1,4-Trimethyl-,(-α-R,2S)-Rel-(9Ci) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity and assay. Our quality system is designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.