Description

2-Piperazinemethanethiol,-α-,1,4-Trimethyl-,(-α-R,2R)-Rel-(9Ci) is a chiral piperazine derivative bearing a thiol functional group, making it a valuable building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical research and development laboratories require this high-purity chiral intermediate to synthesize novel therapeutic agents with specific stereochemical configurations.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal complexation studies.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and synthesis of peptidomimetic compounds for drug discovery.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme mechanisms and biological pathways.
• Asymmetric Catalysis: Potential use as a precursor for chiral catalysts or auxiliaries in stereoselective synthesis.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	2-Piperazinemethanethiol,-α-,1,4-Trimethyl-,(-α-R,2R)-Rel-(9Ci)
CAS No.	221056-40-2
Molecular Formula	C8H18N2S
Molecular Weight	174.31 g/mol
Synonyms	(2R)-1,4-Dimethyl-2-[(methylsulfanyl)methyl]piperazine; (R)-1,4-Dimethyl-2-((methylthio)methyl)piperazine; (αR,2R)-rel-α,1,4-Trimethyl-2-piperazinemethanethiol; 2-Piperazinemethanethiol, α,1,4-trimethyl-, (αR,2R)-rel- (9CI); (2R)-1,4-Dimethyl-2-[(methylthio)methyl]piperazine; 221056-40-2; (R)-1,4-Dimethyl-2-(methylthiomethyl)piperazine
EINECS	Contact for details

Quality Control

Our 2-Piperazinemethanethiol,-α-,1,4-Trimethyl-,(-α-R,2R)-Rel-(9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.