Description

(R)-3-Aminopiperidin-2-One is a chiral, non-natural amino acid derivative and a key building block in modern pharmaceutical synthesis. This compound matters as a versatile intermediate for constructing complex molecules with high stereochemical purity, which is critical for developing active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for applications in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetics Research: Used in the design and construction of peptide analogs and constrained scaffolds to modulate biological activity and stability.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Agrochemical Development: Potential use as a building block for creating novel, chiral active ingredients in crop protection agents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of candidate drugs under GMP or non-GMP conditions.

Basic Information

Product Name	(R)-3-Aminopiperidin-2-One
CAS No.	220928-01-8
Molecular Formula	C5H10N2O
Molecular Weight	114.15 g/mol
Synonyms	(R)-3-Amino-2-piperidinone; (3R)-3-Aminopiperidin-2-one; (R)-3-Amino-delta2-piperidinone; (R)-2-Oxo-3-aminopiperidine; (R)-3-Azanylpiperidin-2-one; (3R)-3-Amino-2-piperidinone; (R)-3-Aminopiperidinone
EINECS	Contact for details

Quality Control

Our (R)-3-Aminopiperidin-2-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.