Description

(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)(4-(2-Hydroxyethyl)Piperazin-1-Yl) Methanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining a benzodioxane and a hydroxyethyl piperazine moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) drugs, receptor modulators, and other specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new chemical entities (NCEs), particularly for CNS-targeting therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Ligand Synthesis: Serves as a core scaffold for creating selective ligands for various neurotransmitter receptors (e.g., serotonin, dopamine receptors).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study specific biological pathways and mechanisms of action.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis projects and pharmacological studies.

Basic Information

Item	Details
Product Name	(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)(4-(2-Hydroxyethyl)Piperazin-1-Yl) Methanone
CAS No.	219851-02-2
Molecular Formula	C15H20N2O4
Molecular Weight	292.33 g/mol
Synonyms	2-(4-(2,3-Dihydrobenzo[b][1,4]dioxine-2-carbonyl)piperazin-1-yl)ethanol; 1-(2-Hydroxyethyl)-4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine; 2,3-Dihydro-1,4-benzodioxin-2-carboxylic acid 4-(2-hydroxyethyl)piperazinyl ester; 4-(2-Hydroxyethyl)-1-piperazinecarboxylic acid 2,3-dihydro-1,4-benzodioxin-2-yl ester; (2,3-Dihydro-1,4-benzodioxin-2-yl)[4-(2-hydroxyethyl)-1-piperazinyl]methanone
EINECS	Contact for details

Quality Control

Our (2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)(4-(2-Hydroxyethyl)Piperazin-1-Yl) Methanone is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) are provided with each batch, detailing all relevant specifications. Production can be aligned with cGMP (current Good Manufacturing Practice) guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.