Description

2,5-Piperazinedione, 1-Acetyl-3-Methylene- (9Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex pharmacologically active molecules, particularly those containing piperazine and diketopiperazine scaffolds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained peptides due to its diketopiperazine core structure.
• Agrochemical Development: Acts as a precursor in the creation of new active ingredients for crop protection products.
• Chemical Biology Probes: Employed in the development of chemical probes for studying enzyme function and protein-protein interactions.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating novel polymers with specific thermal or mechanical properties.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploratory synthesis projects.

Basic Information

Product Name	2,5-Piperazinedione, 1-Acetyl-3-Methylene- (9Ci)
CAS No.	219608-32-9
Molecular Formula	C7H8N2O3
Molecular Weight	168.15 g/mol
Synonyms	1-Acetyl-3-methylenepiperazine-2,5-dione; 3-Methylene-1-acetyl-2,5-piperazinedione; 1-Acetyl-3-methylenediketopiperazine; N-Acetyl-3-methylenediketopiperazine; 3-Methylene-1-acetyldiketopiperazine; Diketopiperazine, 1-acetyl-3-methylene-; (9CI) Index name
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione, 1-Acetyl-3-Methylene- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.