Description

1-Boc-4-Ethoxycarbonyl Piperazine is a high-purity, protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering precise control over molecular architecture. It is primarily utilized by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and as kinase inhibitors.
• Peptidomimetic Chemistry: Used to introduce the piperazine moiety into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing chelating ligands and organocatalysts.
• Agrochemical Synthesis: Employed in the research and production of novel herbicides and fungicides.
• Custom Chemical Synthesis: Provides a protected, bifunctional handle for multi-step synthetic routes in contract research and manufacturing (CRO/CMO).
• Academic & Industrial Research: A valuable reagent for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	1-Boc-4-Ethoxycarbonyl Piperazine
CAS No.	219509-82-7
Molecular Formula	C12H22N2O4
Molecular Weight	258.31 g/mol
Synonyms	1-Boc-4-(ethoxycarbonyl)piperazine; tert-Butyl 4-(ethoxycarbonyl)piperazine-1-carboxylate; 4-(Ethoxycarbonyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-N-ethoxycarbonylpiperazine; Piperazine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; BOC-Pip-OEt; N-Boc-N'-ethoxycarbonylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Ethoxycarbonyl Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.