Description

tert-Butyl 4-(4-Chlorophenyl)-4-cyanopiperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core functionalized with chlorophenyl and cyano groups. This compound is critical for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process development and scale-up of novel drug candidates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent drug candidates, especially those targeting neurological receptors.
• API Synthesis: Serves as a key building block for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry Research: Used in research and development (R&D) for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in process development, route scouting, and pilot-scale production for new chemical entities (NCEs).
• Contract Manufacturing: Supplied to CDMOs and custom synthesis facilities for the production of proprietary compounds under cGMP conditions.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	tert-Butyl 4-(4-Chlorophenyl)-4-cyanopiperidine-1-carboxylate
CAS No.	218451-34-4
Molecular Formula	C17H21ClN2O2
Molecular Weight	320.82 g/mol
Synonyms	1-Boc-4-(4-chlorophenyl)-4-cyanopiperidine; 4-Cyano-4-(4-chlorophenyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-cyano-4-(4-chlorophenyl)piperidine-1-carboxylate; 4-(4-Chlorophenyl)-4-cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(4-chlorophenyl)-4-cyanopiperidine; BOC-4-(4-Chlorophenyl)-4-cyanopiperidine; 218451-34-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Chlorophenyl)-4-cyanopiperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production can adhere to cGMP guidelines for pharmaceutical applications upon request, ensuring traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.