Description

5H-Cyclopenta[E]Pyrrolo[1,2-A]Pyrazin-5-One,3-Amino-3,3A,4,9A-Tetrahydro-,(3R,3As,9Ar)-Rel-(9Ci) CAS NO 216490-82-3 is a high-purity, stereochemically defined heterocyclic compound with significant synthetic utility. This advanced pharmaceutical intermediate is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily targeted at research and development organizations within the pharmaceutical and biotechnology sectors, where it is used to construct complex molecular architectures for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical entities.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Academic & Institutional Research: Utilized in synthetic organic chemistry laboratories for methodological development and the study of novel heterocyclic reactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's outsourced R&D and production needs.

Basic Information

Product Name	5H-Cyclopenta[E]Pyrrolo[1,2-A]Pyrazin-5-One,3-Amino-3,3A,4,9A-Tetrahydro-,(3R,3As,9Ar)-Rel-(9Ci)
CAS No.	216490-82-3
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	(3R,3aS,9aR)-3-Amino-2,3,3a,4-tetrahydro-1H-cyclopenta[e]pyrrolo[1,2-a]pyrazin-5(9aH)-one; rel-(3R,3aS,9aR)-3-Amino-1,3,3a,4-tetrahydrocyclopenta[e]pyrrolo[1,2-a]pyrazin-5(9aH)-one; 3-Amino-3,3a,4,9a-tetrahydro-5H-cyclopenta[e]pyrrolo[1,2-a]pyrazin-5-one (rel-(3R,3aS,9aR)-form); 216490-82-3; Cyclopenta[e]pyrrolo[1,2-a]pyrazin-5-one, 3-amino-3,3a,4,9a-tetrahydro-, (3R,3aS,9aR)-rel-; A key pyrrolopyrazine derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral purity, and impurity profiles. We support development under quality agreements and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.