Description

1-Boc-4-Cyano-4-(2,4-Difluorophenyl)-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold with cyano and difluorophenyl substituents. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Protease Inhibitor Development: Serves as a core structural motif in the research and synthesis of protease inhibitor compounds.
• CNS Drug Discovery: Employed in the development of novel therapeutics targeting neurological and psychiatric disorders.
• Oncology Research: Utilized in the synthesis of potential anti-cancer agents due to its functionalized piperidine structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Institutional Research: Used in university and institutional laboratories for chemical biology and synthetic methodology studies.

Basic Information

Product Name	1-Boc-4-Cyano-4-(2,4-Difluorophenyl)-Piperidine
CAS No.	216311-12-5
Molecular Formula	C17H20F2N2O2
Molecular Weight	322.35 g/mol
Synonyms	1-Boc-4-cyano-4-(2,4-difluorophenyl)piperidine; tert-Butyl 4-cyano-4-(2,4-difluorophenyl)piperidine-1-carboxylate; 4-Cyano-4-(2,4-difluorophenyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(2,4-difluorophenyl)piperidine; 4-(2,4-Difluorophenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester; BOC-4-Cyano-4-(2,4-Difluorophenyl)Piperidine; 216311-12-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 1-Boc-4-Cyano-4-(2,4-Difluorophenyl)-Piperidine is characterized and controlled using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to guarantee identity, purity, and consistency. We adhere to strict in-process controls and final release specifications. Certificates of Analysis (COA) detailing all critical quality attributes are available upon request and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.