Description

C18 ((-2'-Hydroxy) Dihydro Ceramide (D18:0/18:0) is a high-purity, synthetic ceramide analog, a critical building block in the stratum corneum's lipid matrix. This compound is essential for research and development in advanced skincare and pharmaceutical formulations, where it serves as a key structural component to mimic and enhance the skin's natural barrier function. It is primarily utilized by R&D scientists and product developers in the cosmetic, dermatological, and lipid biochemistry sectors for creating next-generation moisturizers, barrier repair creams, and model membrane systems.

Application

• Advanced Cosmetic Formulations: As a primary active ingredient in high-end moisturizers, anti-aging serums, and barrier repair products to improve skin hydration and elasticity.
• Dermatological Research: Used in vitro and ex vivo studies to investigate skin barrier function, lipid metabolism, and the pathophysiology of conditions like atopic dermatitis and psoriasis.
• Biomimetic Membrane Systems: A key component for constructing artificial lipid bilayers and vesicles to study membrane permeability, protein-lipid interactions, and drug delivery mechanisms.
• Pharmaceutical Development: Incorporated into topical drug delivery systems to enhance skin penetration and stability of active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in laboratories analyzing cosmetic and pharmaceutical products.
• Hair Care Products: Used in formulations aimed at repairing and strengthening the hair cuticle, improving shine and manageability.

Basic Information

Product Name	C18 ((-2'-Hydroxy) Dihydro Ceramide (D18:0/18:0)
CAS No.	215528-91-9
Molecular Formula	C36H73NO4
Molecular Weight	583.98 g/mol
Synonyms	N-Octadecanoyl-D-erythro-sphinganine; Dihydroceramide (d18:0/18:0); N-Stearoylsphinganine; (2S,3R)-2-Octadecanamidooctadecane-1,3-diol; Cer(d18:0/18:0); C18 Dihydroceramide; Phytosphingosine-based ceramide analog; 2'-Hydroxy dihydroceramide
EINECS	Contact for details

Quality Control

Our C18 ((-2'-Hydroxy) Dihydro Ceramide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality ensures material suitable for research, cosmetic, and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.