Description

tert-Butyl 4-(Dimethylcarbamoyl)Piperazine-1-Carboxylate, 1-(tert-Butoxycarbonyl)-4-(Dimethylcarbamoyl)Piperazine CAS NO 215453-81-9 is a high-purity, protected piperazine derivative serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules, particularly in medicinal chemistry for drug discovery and development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop novel therapeutic compounds.
• Peptidomimetic Synthesis: Serves as a constrained scaffold in the design of peptide mimics to improve metabolic stability and bioavailability.
• Agrochemical Development: Intermediate in the creation of novel fungicides, herbicides, and insecticides requiring specific piperazine-based architectures.
• Ligand and Catalyst Preparation: Precursor for synthesizing specialized ligands used in asymmetric catalysis and metal complexation.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke client projects.

Basic Information

Product Name	tert-Butyl 4-(Dimethylcarbamoyl)Piperazine-1-Carboxylate, 1-(tert-Butoxycarbonyl)-4-(Dimethylcarbamoyl)Piperazine
CAS No.	215453-81-9
Molecular Formula	C12H23N3O3
Molecular Weight	257.33 g/mol
Synonyms	1-Boc-4-(dimethylcarbamoyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)piperazine; 4-(Dimethylcarbamoyl)-1-(tert-butoxycarbonyl)piperazine; tert-Butyl 4-(dimethylaminocarbonyl)piperazine-1-carboxylate; N-Boc-4-(dimethylcarbamoyl)piperazine; Piperazine, 4-(dimethylcarbamoyl)-1-[(1,1-dimethylethoxy)carbonyl]-; BOC-Piperazine-4-carboxamide, N,N-dimethyl-; 215453-81-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Dimethylcarbamoyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.