Description

Pi(4)P, Di C16 is a synthetic, cell-permeable phosphatidylinositol 4-phosphate (PI4P) analog, a critical signaling lipid in eukaryotic cell biology. This high-purity biochemical tool is essential for researchers investigating intracellular lipid signaling pathways, membrane trafficking, and phosphoinositide metabolism. It is primarily used by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cell biology, neurobiology, and metabolic disease research.

Application

• Biochemical Research: As a substrate or standard in enzymatic assays to study PI4-kinases, phosphatases, and lipid transfer proteins.
• Cell Signaling Studies: To directly modulate PI4P levels in live cells for investigating its role in Golgi function, plasma membrane identity, and ion channel regulation.
• Lipidomics & Analytical Standards: Serves as a critical reference standard for the identification and quantification of PI4P species in complex biological samples via LC-MS/MS.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify novel inhibitors or activators of enzymes in the phosphoinositide pathway.
• Membrane Biophysics: For the reconstitution of lipid bilayers and vesicles to study protein-lipid interactions and membrane dynamics.
• Neuroscience Research: Investigating the role of phosphoinositides in synaptic vesicle recycling, neurotransmitter release, and neuronal development.

Basic Information

Product Name	Pi(4)P, Di C16
CAS No.	214332-61-3
Molecular Formula	C41H78O16P2
Molecular Weight	888.99 g/mol
Synonyms	1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate); Phosphatidylinositol 4-phosphate (16:0 PI4P); PI4P (dipalmitoyl); L-α-Phosphatidylinositol-4-phosphate, dipalmitoyl; PtdIns(4)P; PtdIns4P; Dipalmitoyl Phosphatidylinositol 4-Phosphate; Inositol phospholipid
EINECS	Contact for details

Quality Control

Every batch of Pi(4)P, Di C16 is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for sensitive research applications. Our standard grade meets specifications suitable for cell-based and biochemical assays. Comprehensive Certificates of Analysis (COA) detailing purity, identity confirmation, and impurity profiles are provided with each shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized. Aliquot contents upon receipt to minimize freeze-thaw cycles and exposure to air. Allow the sealed vial to equilibrate to room temperature before opening.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.