Description

(8Z,11Z,14Z)-5,6-Dihydroxyicosa-8,11,14-Trienoic Acid is a specialized dihydroxy fatty acid derivative of linolenic acid, serving as a key intermediate in the synthesis of bioactive lipid mediators. This compound is valued for its role in research focused on eicosanoid pathways, inflammation, and cellular signaling mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing novel therapeutic agents and conducting advanced biochemical studies.

Application

• Biochemical Research: Critical intermediate for studying the biosynthesis and metabolic pathways of eicosanoids, including leukotrienes and lipoxins.
• Pharmaceutical Development: Used as a building block or reference standard in the R&D of anti-inflammatory and immunomodulatory drugs.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the role of specific hydroxy fatty acids in cellular communication and inflammation.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in analytical laboratories.
• Enzymology: Substrate for studies involving lipoxygenase and cytochrome P450 enzymes to understand their catalytic mechanisms.
• Synthetic Chemistry: A valuable chiral synthon for the total synthesis of complex natural products and bioactive lipids.

Basic Information

Product Name	(8Z,11Z,14Z)-5,6-Dihydroxyicosa-8,11,14-Trienoic Acid
CAS No.	213382-49-1
Molecular Formula	C₂₀H₃₄O₄
Molecular Weight	338.48 g/mol
Synonyms	5,6-DiHETE; 5,6-Dihydroxy-8Z,11Z,14Z-eicosatrienoic Acid; 5,6-DiHETrE; (5S,6S)-5,6-Dihydroxyicosa-8,11,14-trienoic Acid; 5,6-Dihydroxy-8,11,14-eicosatrienoic Acid; AA-5,6-diol; Arachidonic Acid 5,6-Diol
EINECS	Contact for details

Quality Control

Our (8Z,11Z,14Z)-5,6-Dihydroxyicosa-8,11,14-Trienoic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.