Description

3-Iodopyrazine-2-Carboxylic Acid is a high-purity, functionalized heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile handle for cross-coupling reactions and further derivatization, enabling the rapid construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the pyrazine core for bioactivity.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig aminations.
• Heterocyclic Chemistry: A fundamental building block for constructing more complex fused or substituted pyrazine and diazine derivatives.

Basic Information

Product Name	3-Iodopyrazine-2-Carboxylic Acid
CAS No.	212471-40-4
Molecular Formula	C5H3IN2O2
Molecular Weight	249.99 g/mol
Synonyms	2-Pyrazinecarboxylic acid, 3-iodo-; 3-Iodo-2-pyrazinecarboxylic acid; 3-Iodopyrazine-2-carboxylic acid; 212471-40-4; 3-Iodo-pyrazine-2-carboxylic acid; 3-Iodopyrazinecarboxylic acid; 3-Iodo-2-carboxypyrazine
EINECS	Contact for details

Quality Control

Our 3-Iodopyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.