Description

2-Piperidinecarboxylicacid,4-Hydroxy-,Methylester,(2S,4R)-(9Ci) is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering precise stereochemical control essential for developing active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Peptidomimetic Chemistry: Serves as a constrained proline analogue for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations to induce enantioselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in regulatory filings.

Basic Information

Product Name	2-Piperidinecarboxylicacid,4-Hydroxy-,Methylester,(2S,4R)-(9Ci)
CAS No.	211058-80-9
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(2S,4R)-4-Hydroxypipecolic Acid Methyl Ester; Methyl (2S,4R)-4-Hydroxypipecolate; (2S,4R)-Methyl 4-Hydroxypipecolate; 4-Hydroxy-L-pipecolic Acid Methyl Ester; (2S,4R)-1-Methyl 4-hydroxypiperidine-2-carboxylate; 4-Hydroxy-D-proline Methyl Ester (piperidine analogue); trans-4-Hydroxy-L-pipecolic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 2-Piperidinecarboxylicacid,4-Hydroxy-,Methylester,(2S,4R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.