Description

3-[2-[4-(3,4-Dimethylphenyl)-1-Piperazinyl]Ethyl]-2,3-Dihydro-1H-Isoindol-1-Onedihydrochloride is a high-purity, non-racemic pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and cardiovascular domains.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of complex drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Serves as a building block for the final construction of Active Pharmaceutical Ingredients (APIs) targeting specific receptors.
• Process Chemistry: Employed in scale-up and process development for new chemical entities (NCEs).
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Asymmetric Synthesis: Leveraged in chiral synthesis due to its defined stereochemistry to introduce desired biological activity.

Basic Information

Item	Details
Product Name	3-[2-[4-(3,4-Dimethylphenyl)-1-Piperazinyl]Ethyl]-2,3-Dihydro-1H-Isoindol-1-Onedihydrochloride
CAS No.	210688-56-5
Molecular Formula	C22H28N3O·2HCl
Molecular Weight	439.40 g/mol
Synonyms	1-(2-(1-Oxo-2,3-dihydro-1H-isoindol-3-yl)ethyl)-4-(3,4-dimethylphenyl)piperazine dihydrochloride; (S)-3-[2-[4-(3,4-Dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride; L-765,314; L765314; L 765314; (S)-L-765,314 dihydrochloride; 3-[2-[4-(3,4-Dimethylphenyl)-1-piperazinyl]ethyl]isoindolin-1-one dihydrochloride
EINECS	Contact for details

Quality Control

Our 3-[2-[4-(3,4-Dimethylphenyl)-1-Piperazinyl]Ethyl]-2,3-Dihydro-1H-Isoindol-1-Onedihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.