Description

3-(2-Trifluoromethyl-Phenyl)-Acryloyl Chloride is a high-value, reactive organic intermediate featuring a trifluoromethylphenyl group and an acryloyl chloride moiety. This compound is essential for introducing the biologically active trifluoromethylphenylacrylamide scaffold into target molecules, significantly enhancing their lipophilicity and metabolic stability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Acts as a precursor for synthesizing fluorinated compounds used in electronic display technologies.
• Chemical Biology Probes: Utilized in the development of activity-based probes and covalent inhibitors for proteomics research and target validation.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-(2-Trifluoromethyl-Phenyl)-Acryloyl Chloride
CAS No.	209619-25-0
Molecular Formula	C10H6ClF3O
Molecular Weight	234.60 g/mol
Synonyms	2-(Trifluoromethyl)cinnamoyl chloride; (E)-3-[2-(Trifluoromethyl)phenyl]prop-2-enoyl chloride; 3-[2-(Trifluoromethyl)phenyl]-2-propenoyl chloride; α,β-Unsaturated acid chloride with trifluoromethyl group; (2-Trifluoromethylphenyl)acryloyl chloride; TFM-Cinnamoyl Chloride; 209619-25-0; (E)-3-(2-(Trifluoromethyl)phenyl)acryloyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Trifluoromethyl-Phenyl)-Acryloyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) including results for assay, identity, and impurity profiles (by HPLC, GC, and NMR) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from strong bases, oxidizers, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.