Description

m-Peg3-Acid CAS NO 209542-49-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a carboxylic acid group at one terminus and a methoxy group at the other. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise modification of biomolecules to enhance solubility, stability, and pharmacokinetic properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating PEGylated therapeutics, diagnostic agents, and functionalized polymers.

Application

• Pharmaceutical Linker: Serves as a key spacer and linker in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• PEGylation Reagent: Used to modify peptides, proteins, and small molecule drugs to improve their solubility, reduce immunogenicity, and prolong circulation half-life.
• Bioconjugation Chemistry: The terminal carboxylic acid group facilitates covalent attachment to amines via amide bond formation, enabling the functionalization of surfaces, nanoparticles, and biomolecules.
• Polymer Synthesis: Acts as a monomer or macroinitiator for creating functionalized, biocompatible PEG-based copolymers and hydrogels.
• Diagnostic Probes: Employed in the development of contrast agents and fluorescent probes for imaging applications.
• Drug Delivery Systems: Incorporated into micelles, liposomes, and dendrimers to create smart delivery vehicles with enhanced targeting capabilities.

Basic Information

Item	Details
Product Name	m-Peg3-Acid
CAS No.	209542-49-4
Molecular Formula	C10H20O6
Molecular Weight	236.26 g/mol
Synonyms	3,6,9-Trioxaundecanedioic acid, 11-methoxy-; 11-Methoxy-3,6,9-trioxaundecanedioic acid; Methoxy-PEG3-acid; mPEG3-COOH; α-Methoxy-ω-carboxy triethylene glycol; O-(2-Carboxyethyl)-O'-(2-methoxyethyl)diethylene glycol; mPEG(3) propionic acid; PEG-based carboxylic acid linker
EINECS	Contact for details

Quality Control

Our m-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under an inert atmosphere, consider.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.