Description

tert-Butyl 4-(Difluoromethylene)piperidine-1-carboxylate is a high-value, fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluoromethylene group, is essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of bioactive molecules, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance bioavailability and environmental stability.
• Fluorine Chemistry Building Block: Serves as a versatile precursor for introducing the difluoromethylene moiety into more complex molecular architectures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Potential intermediate in the synthesis of fluorinated polymers or liquid crystals with specialized properties.

Basic Information

Product Name	tert-Butyl 4-(Difluoromethylene)piperidine-1-carboxylate
CAS No.	208245-65-2
Molecular Formula	C11H17F2NO2
Molecular Weight	233.26 g/mol
Synonyms	1-Boc-4-(difluoromethylene)piperidine; 4-(Difluoromethylene)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(difluoromethylene)-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(difluoromethylene)piperidine; N-Boc-4-(difluoromethylene)piperidine; 208245-65-2; 4-Difluoromethylene-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 4-(Difluoromethylene)piperidine-1-carboxylate is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.