Description

n-Boc-N’-(2-Chloroethyl)Piperazine, Hydrochloride Salt is a protected piperazine derivative of significant importance in advanced organic synthesis. This compound serves as a crucial bifunctional building block, offering both a reactive chloroethyl group and a Boc-protected secondary amine for selective manipulation. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecules, particularly in medicinal chemistry programs targeting novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antipsychotics, and other nitrogen-containing heterocycles.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce piperazine-linked side chains with further functionalization potential.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides that incorporate piperazine motifs.
• Chemical Biology: Useful for creating molecular probes and linker systems in bioconjugation and proteomics research.
• Custom Synthesis: Serves as a versatile starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.

Basic Information

Product Name	n-Boc-N’-(2-Chloroethyl)Piperazine, Hydrochloride Salt
CAS No.	208167-83-3
Molecular Formula	C11H22Cl2N2O2
Molecular Weight	285.21 g/mol
Synonyms	1-Boc-4-(2-Chloroethyl)piperazine hydrochloride; tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate hydrochloride; 4-(2-Chloroethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; N-Boc-4-(2-Chloroethyl)piperazine HCl; 1-(tert-Butoxycarbonyl)-4-(2-chloroethyl)piperazine hydrochloride; N-Boc-N'-(2-Chloroethyl)piperazine hydrochloride; Piperazine, 1-(2-chloroethyl)-4-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our n-Boc-N’-(2-Chloroethyl)Piperazine, Hydrochloride Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee reliable performance in your synthetic sequences.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.