Description

n-(3-Chloro-4-Fluorobenzoyl)-4-Fluoro-4-n-(3-Chloro-4-Fluorobenzoyl)-4-Fluoro-4-Hydroxymethylpiperidine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally defined building block essential for achieving precise molecular architecture in modern drug discovery and development. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in creating novel therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of proprietary drug candidates and investigational new drugs.
• API Synthesis: Serves as a crucial building block for constructing complex molecular scaffolds in Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry Research: Used in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production runs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in API production.

Basic Information

Product Name	n-(3-Chloro-4-Fluorobenzoyl)-4-Fluoro-4-n-(3-Chloro-4-Fluorobenzoyl)-4-Fluoro-4-Hydroxymethylpiperidine
CAS No.	208111-36-8
Molecular Formula	C20H16Cl2F4N2O3
Molecular Weight	479.26 g/mol
Synonyms	4-Fluoro-4-(hydroxymethyl)-N-[3-chloro-4-fluorobenzoyl]piperidine; 1-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-(hydroxymethyl)piperidine; 4-Fluoro-4-(hydroxymethyl)-1-(3-chloro-4-fluorobenzoyl)piperidine; 208111-36-8; 4-Fluoro-4-hydroxymethyl-1-(3-chloro-4-fluorobenzoyl)piperidine; 1-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-piperidinemethanol; 4-Fluoro-4-(hydroxymethyl)-N-(3-chloro-4-fluorobenzoyl)piperidine; Piperidine, 4-fluoro-4-(hydroxymethyl)-1-[(3-chloro-4-fluorophenyl)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-(3-Chloro-4-Fluorobenzoyl)-4-Fluoro-4-Hydroxymethylpiperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects requiring compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.