Description

tert-Butyl 4-(3-Nitrophenyl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core and nitro-substituted aromatic ring. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological receptors.
• Chemical Research & Development: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in medicinal chemistry.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step manufacturing process of complex APIs, especially those containing functionalized piperazine moieties.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	tert-Butyl 4-(3-Nitrophenyl)Piperazine-1-Carboxylate
CAS No.	206879-94-9
Molecular Formula	C15H21N3O4
Molecular Weight	307.35 g/mol
Synonyms	1-Boc-4-(3-nitrophenyl)piperazine; tert-Butyl 4-(3-nitrophenyl)-1-piperazinecarboxylate; 4-(3-Nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(3-nitrophenyl)piperazine; 3-Nitrophenylpiperazine Boc-protected; Boc-4-(3-NO2-Ph)-piperazine; N-Boc-3-nitrophenylpiperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Nitrophenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.