Description

4-(3-Amino-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in modern pharmaceutical synthesis. Its bifunctional nature, featuring both a reactive aromatic amine and a protected secondary amine, makes it an invaluable intermediate for constructing complex molecular scaffolds. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, such as antipsychotics and antidepressants.
• Chemical Synthesis Building Block: Used to introduce the 3-aminophenyl-piperazine moiety into larger molecules for structure-activity relationship (SAR) studies.
• Ligand and Receptor Probe Development: Employed in medicinal chemistry research for creating selective ligands for serotonin and dopamine receptor subtypes.
• Custom Synthesis and Contract Manufacturing: Serves as a starting material for custom synthesis projects requiring high-fidelity, multi-step organic transformations.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with specific biological activity.

Basic Information

Product Name	4-(3-Amino-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	206879-72-3
Molecular Formula	C15H23N3O2
Molecular Weight	277.36 g/mol
Synonyms	tert-Butyl 4-(3-aminophenyl)piperazine-1-carboxylate; 1-Boc-4-(3-aminophenyl)piperazine; 4-(3-Aminophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(3-aminophenyl)piperazine; 3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)aniline; 4-(3-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester; 206879-72-3; Boc-4-(3-aminophenyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(3-Amino-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.