Description

1-Piperazinecarboxylic Acid, 4-[2-(2-Propyn-1-Yloxy)Ethyl]-, 1,1-Dimethylethyl Ester is a high-purity, synthetically valuable piperazine derivative featuring a propargyl ether side chain and a tert-butyloxycarbonyl (Boc) protecting group. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality building blocks for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile reactive sites.
• Peptidomimetic Synthesis: Serves as a constrained scaffold or linker in the design of peptide-like bioactive compounds.
• Agrochemical Development: Employed in the research and production of new-generation pesticides and herbicides.
• Click Chemistry Reagent: The alkyne (propynyl) functionality enables its use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer chemistry.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands for metal catalysis or as a precursor for functionalized materials.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 4-[2-(2-Propyn-1-Yloxy)Ethyl]-, 1,1-Dimethylethyl Ester
CAS No.	206862-65-9
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	tert-Butyl 4-(2-(prop-2-yn-1-yloxy)ethyl)piperazine-1-carboxylate; 1-Boc-4-(2-(prop-2-yn-1-yloxy)ethyl)piperazine; Boc-Piperazine-CH2CH2-O-CH2-C≡CH; 4-(2-(Prop-2-yn-1-yloxy)ethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-(propargyloxy)ethyl)piperazine; 1-(tert-Butoxycarbonyl)-4-[2-(prop-2-yn-1-yloxy)ethyl]piperazine; Propargyl-PEG2-Boc-piperazine; 206862-65-9
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 4-[2-(2-Propyn-1-Yloxy)Ethyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.