Description

2-Bromo-3-Fluoropyrazine is a versatile and high-value halogenated heterocyclic building block essential for modern synthetic chemistry. Its unique structure, featuring both bromine and fluorine substituents on the pyrazine ring, makes it a critical intermediate for introducing complexity and specific functionality into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the creation of specialized ligands, functionalized polymers, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille), enabling rapid diversification of molecular scaffolds.
• Fluorination Chemistry Studies: A valuable substrate for studying nucleophilic aromatic substitution (SNAr) and other fluorination-related mechanistic pathways.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	2-Bromo-3-Fluoropyrazine
CAS No.	206278-27-5
Molecular Formula	C4H2BrFN2
Molecular Weight	176.97 g/mol
Synonyms	3-Fluoro-2-bromopyrazine; 2-Bromo-3-fluoropyrazine; Pyrazine, 2-bromo-3-fluoro-; 3-Fluoropyrazine, 2-bromo-; Fluorobromopyrazine; 2-Bromo-3-fluoro-1,4-diazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluoropyrazine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.