Description

1-n-Boc-2-(Hydroxymethyl)Piperazine is a versatile and highly functionalized piperazine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the orthogonal protection of the piperazine nitrogen and the reactive hydroxymethyl group, enabling precise, multi-step molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs), complex ligands, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Synthesis: Employed in the research and development of advanced herbicides and fungicides with specific stereochemical requirements.
• Custom Chemical Synthesis: A valuable starting material for contract research organizations (CROs) and CDMOs building bespoke molecular libraries for client projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	1-n-Boc-2-(Hydroxymethyl)Piperazine
CAS No.	205434-75-9
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	1-Boc-2-(Hydroxymethyl)Piperazine; 2-(Hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperazine; N-Boc-2-piperazinemethanol; (2-Hydroxymethyl-piperazin-1-yl)-carbamic acid tert-butyl ester; 1-N-Boc-2-Hydroxymethylpiperazine; 1-Boc-2-piperazinemethanol
EINECS	Contact for details

Quality Control

Our 1-n-Boc-2-(Hydroxymethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.