Description

Tubulysin B CAS NO 205304-87-6 is a highly potent cytotoxic peptide, originally isolated from myxobacteria, belonging to the tubulysin family of natural products. It is a microtubule-destabilizing agent that exhibits exceptional anti-mitotic activity, making it a compound of significant interest in advanced pharmaceutical research. This product is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel anticancer therapeutics and antibody-drug conjugates (ADCs).

Application

• Anticancer Drug Discovery: Serves as a key payload or reference standard in the research and development of novel chemotherapeutic agents targeting tubulin polymerization.
• Antibody-Drug Conjugate (ADC) Payload: Used as a highly potent warhead in the synthesis and evaluation of targeted ADC therapies due to its mechanism of action and potency.
• Biochemical Research: Employed as a critical tool compound in cell biology studies to investigate microtubule dynamics, cell cycle arrest, and apoptosis mechanisms.
• Pharmaceutical Reference Standard: Acts as an analytical standard for quality control, method development, and purity assessment in pharmaceutical manufacturing and regulatory submissions.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicology profiles of potential drug candidates.

Basic Information

Product Name	Tubulysin B
CAS No.	205304-87-6
Molecular Formula	C₄₅H₆₇N₅O₁₀S
Molecular Weight	870.11 g/mol
Synonyms	Tubulysin B; Tubulysin B (free base); (-)-Tubulysin B; Tubulysin B, from *Archangium gephyra*; TUB B; Antibiotic TUB B; Tubugis; Contact for details on additional aliases.
EINECS	Contact for details

Quality Control

Our Tubulysin B is produced under strict quality management protocols to ensure the highest standards of purity and consistency required for pharmaceutical research. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our rigorous specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the container under an inert atmosphere and desiccated to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.