Description

Tubulysin A (Tuba) is a highly potent, naturally occurring cytotoxic peptide that targets microtubule dynamics, leading to the inhibition of cell division and apoptosis. Its exceptional potency makes it a compound of significant interest for the development of next-generation targeted cancer therapeutics and antibody-drug conjugates (ADCs). This product is essential for pharmaceutical R&D, academic research in oncology, and biotechnology companies focused on novel chemotherapeutic agents and payload synthesis.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent cytotoxic warhead in the development of targeted cancer therapies.
• Oncology Research: Used as a reference standard and active compound in studies investigating microtubule inhibition, cell cycle arrest, and apoptosis mechanisms.
• Pharmaceutical Development: A key intermediate in the synthesis and preclinical evaluation of novel chemotherapeutic candidates.
• Chemical Biology: Employed as a molecular probe to study tubulin dynamics and intracellular transport processes.
• Bioconjugation Studies: Utilized in research focused on linker technology and optimizing the stability and efficacy of drug conjugates.

Basic Information

Product Name	Tubulysin A (Tuba)
CAS No.	205304-86-5
Molecular Formula	C₄₃H₆₅N₅O₁₀S
Molecular Weight	844.07 g/mol
Synonyms	Tubulysin A; Tuba; (-)-Tubulysin A; Tubulysin A, Tuba; Tubulysin A (Tuba); Tubulysin A, (-)-; Tubulysin A (Tuba) (CAS 205304-86-5); (2S,4R)-4-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-[(2S,5S,8S,11S)-5,8-diisopropyl-11-methyl-2-[[(2S)-1-methylpyrrolidin-2-yl]methyl]-4,7,10-trioxo-3,6,9,12-tetraazatetradecan-14-oyl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Tubulysin A is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC and MS. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere such as argon or nitrogen. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.