Description

Pi(4,5)P2,Di C8 is a synthetic, short-chain diacylglycerol derivative of the critical signaling lipid phosphatidylinositol 4,5-bisphosphate. This compound is essential for biochemical and pharmacological research into phosphoinositide-mediated cell signaling pathways. It is primarily utilized by research scientists and pharmaceutical developers in academic, biotechnology, and drug discovery settings to study membrane dynamics, enzyme kinetics, and receptor interactions.

Application

• Biochemical Research: Used as a substrate or standard in enzymatic assays for kinases, phosphatases, and phospholipases that interact with phosphoinositides.
• Cell Signaling Studies: A vital tool for investigating the role of PI(4,5)P2 in cellular processes such as vesicle trafficking, cytoskeletal reorganization, and ion channel regulation.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify novel inhibitors or activators of phosphoinositide-metabolizing enzymes.
• Lipidomics & Analytical Standards: Serves as a critical reference standard for the identification and quantification of phosphoinositides in complex biological samples using techniques like LC-MS.
• Membrane Biophysics: Used in model membrane systems (e.g., liposomes, lipid bilayers) to study protein-lipid interactions and membrane domain formation.

Basic Information

Product Name	Pi(4,5)P2,Di C8
CAS No.	204858-53-7
Molecular Formula	C29H54O19P3
Molecular Weight	838.66 g/mol
Synonyms	L-α-Phosphatidylinositol-4,5-bisphosphate (DiC8); PI(4,5)P2 (DiC8); 1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate); PtdIns(4,5)P2 (C8); Phosphatidylinositol 4,5-bisphosphate diC8; Dipalmitoyl PI(4,5)P2 (DiC8) (common misnomer); Inositol phospholipid derivative; PIP2 (DiC8)
EINECS	Contact for details

Quality Control

Our Pi(4,5)P2,Di C8 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods are validated to meet the rigorous standards required by the research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol/water mixtures
Water Content (KF)	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.