Description

1-(5-Isoquinolinylsulfonyl)Homopiperazine Dihydrochloride, also known as Fasudil Dihydrochloride, is a potent and selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK). This compound is a critical research-grade biochemical for investigating cellular signaling pathways related to cytoskeletal dynamics, smooth muscle contraction, and neuronal growth. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular, neurological, and oncology research. The high-purity material is essential for reliable and reproducible in vitro and in vivo studies.

Application

• Biochemical Research: A key tool compound for studying the physiological and pathological roles of ROCK isoforms (ROCK1 and ROCK2) in signal transduction.
• Cardiovascular Research: Investigation of vasodilation, hypertension, pulmonary arterial hypertension, and atherosclerosis due to its effects on vascular smooth muscle cell contraction and endothelial function.
• Neurological Research: Exploration of neuroprotection, axonal regeneration, and treatments for cerebral vasospasm, stroke, and spinal cord injury.
• Cell Biology Studies: Used to examine cell migration, adhesion, proliferation, and apoptosis in various cell lines.
• Oncology Research: Study of tumor cell invasion, metastasis, and angiogenesis as ROCK signaling is implicated in cancer progression.
• Pharmacological Reference Standard: Serves as a certified reference material for analytical method development and quality control in pharmaceutical R&D.

Basic Information

Product Name	1-(5-Isoquinolinylsulfonyl)Homopiperazine Dihydrochloride, Fasudil Dihydrochloride
CAS No.	203911-27-7
Molecular Formula	C14H20Cl2N4O2S
Molecular Weight	379.30 g/mol
Synonyms	Fasudil HCl; HA-1077 Dihydrochloride; 1-(5-Isoquinolinesulfonyl)homopiperazine Dihydrochloride; AT877; (1,4-Diazepan-1-ylsulfonyl)(5-isoquinolinyl)amine Dihydrochloride; ROCK Inhibitor Fasudil; 5-Isoquinolinesulfonamide, N-(hexahydro-1H-1,4-diazepin-1-yl)-, Dihydrochloride
EINECS	Contact for details

Quality Control

Our Fasudil Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.