Description

N,o-Bis(Trimethyl-D9-Silyl)Acetamide is a deuterated silylating reagent, a high-purity specialty chemical essential for analytical and synthetic chemistry. Its core value lies in its role as a derivatization agent for gas chromatography-mass spectrometry (GC-MS), where it enhances the volatility and detection of sensitive compounds. This product is critically needed by analytical laboratories, pharmaceutical R&D teams, and chemical manufacturers working with stable isotope labeling, metabolomics, and the synthesis of advanced materials.

Application

• Derivatization Agent for GC-MS Analysis: Used to silylate polar functional groups (e.g., -OH, -COOH, -NH) in complex mixtures like biological samples for metabolomic profiling and drug metabolite identification.
• Stable Isotope Labeling Studies: Serves as a deuterium-labeled reagent in quantitative mass spectrometry for internal standardization, improving accuracy in pharmacokinetic and biomarker research.
• Pharmaceutical Intermediate: Employed in the synthesis of deuterated drug candidates and other labeled compounds for clinical research and development.
• Protecting Group Chemistry: Functions as a trimethylsilyl (TMS) donor in multi-step organic synthesis to protect sensitive functional groups under mild conditions.
• Forensic and Environmental Analysis: Aids in the detection and quantification of trace-level compounds in forensic toxicology and environmental monitoring samples.
• Material Science Research: Used in the surface modification and functionalization of inorganic materials and nanoparticles.

Basic Information

Item	Details
Product Name	N,o-Bis(Trimethyl-D9-Silyl)Acetamide
CAS No.	203784-65-0
Molecular Formula	C8D9H13NOSi2
Molecular Weight	219.44 g/mol
Synonyms	N,O-Bis(trimethyl-d9-silyl)acetamide; BSA-d27; N,O-Bis(trimethylsilyl)acetamide-d27; BSA-d27; Deuterated BSA; N,O-Bis[(2H9)trimethylsilyl]acetamide; Acetamide, N,O-bis(trimethyl-d9-silyl)-; BSTFA-d27 analog (Note: BSTFA is a related compound)
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trimethyl-D9-Silyl)Acetamide is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, isotopic purity (D-enrichment), and impurity profile. We adhere to cGMP principles where applicable to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.