Description

2,5-Dichlorophenylacetyl Chloride is a versatile and highly reactive acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the 2,5-dichlorophenylacetyl moiety, a key structural feature for modulating biological activity and material properties. This intermediate is essential for research and production chemists in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of receptor-targeted molecules.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the dichlorophenyl group enhances compound stability and efficacy.
• Peptide Mimetics & Conjugation: Facilitates the acylation of amines in amino acids or peptides to create novel peptide mimetics or antibody-drug conjugates (ADCs).
• Material Science Research: Employed in the synthesis of specialized monomers or polymers with specific electronic or structural characteristics.
• Chemical Derivatization: Acts as a derivatizing agent in analytical chemistry for the detection or quantification of amine-containing compounds.
• Custom Synthesis & Contract Manufacturing: A crucial reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse R&D projects.

Basic Information

Product Name	2,5-Dichlorophenylacetyl Chloride
CAS No.	203314-48-1
Molecular Formula	C8H5Cl3O
Molecular Weight	223.48 g/mol
Synonyms	2,5-Dichlorobenzeneacetyl Chloride; (2,5-Dichlorophenyl)acetyl Chloride; α-Chloro-2,5-dichloroacetophenone; 2,5-Dichloro-ω-chloroacetophenone; 2,5-Dichlorophenacetyl Chloride; NSC 405124; 2,5-Dichlorobenzeneacetic Acid Chloride
EINECS	Contact for details

Quality Control

Our 2,5-Dichlorophenylacetyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, amines, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.