Description

L-Proline, 4-Amino-3-Hydroxy-, (3S,4R)- (9Ci) is a high-purity, stereochemically defined amino acid derivative of significant interest in advanced pharmaceutical synthesis. This compound matters as a sophisticated chiral building block, enabling the construction of complex molecules with precise three-dimensional control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly peptidomimetics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and metabolic disease research.
• Peptidomimetic Design: Used to introduce constrained, hydroxylated proline analogs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly for hydroxylases and proline-specific enzymes.
• Asymmetric Catalysis: Potential use as a ligand or precursor for chiral catalysts in stereoselective organic transformations.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-Proline, 4-Amino-3-Hydroxy-, (3S,4R)- (9Ci)
CAS No.	202473-18-5
Molecular Formula	C₅H₁₀N₂O₃
Molecular Weight	146.14 g/mol
Synonyms	(3S,4R)-4-Amino-3-hydroxy-L-proline; (3S,4R)-AHYP; 4-Amino-3-hydroxy-L-proline; 4-Amino-3-hydroxyproline; L-4-Amino-3-hydroxyproline; cis-4-Amino-3-hydroxy-L-proline; (2S,4R)-4-Amino-2-pyrrolidinecarboxylic acid, 3-hydroxy-; A building block for collagen analogs
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Amino-3-Hydroxy-, (3S,4R)- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing purity, chiral excess, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (3S,4R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.