Description

1-Methyl-4-(4-(trifluoromethyl)benzyl)piperazine is a specialized piperazine derivative featuring a trifluoromethylbenzyl substituent, a structural motif of significant interest in advanced organic synthesis. This compound matters as a versatile and high-value pharmaceutical intermediate and building block for medicinal chemistry, enabling the development of novel bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated aromatic systems into their target compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Precursor: Employed in the research of advanced polymers and functional materials that require fluorinated aromatic components for specific electronic or surface properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme function and protein-protein interactions within biological systems.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector with tailored, complex organic molecules.

Basic Information

Product Name	1-Methyl-4-(4-(Trifluoromethyl)Benzyl)Piperazine
CAS No.	201682-15-7
Molecular Formula	C13H17F3N2
Molecular Weight	258.28 g/mol
Synonyms	1-Methyl-4-[(4-(trifluoromethyl)phenyl)methyl]piperazine; 4-(Trifluoromethyl)benzyl 1-Methylpiperazine; N-Methyl-4-((4-(trifluoromethyl)benzyl)piperazine; 1-Methyl-4-(4-trifluoromethyl-benzyl)-piperazine; 1-Methyl-4-(α,α,α-trifluoro-p-tolyl)piperazine; 201682-15-7; 4-[(4-Trifluoromethylphenyl)methyl]-1-methylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-(4-(trifluoromethyl)benzyl)piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.