Description

2-Deoxy-D-[1-13C]Arabino-Hexose is a stable isotope-labeled analog of 2-deoxy-D-glucose, where the carbon-1 position is enriched with the non-radioactive 13C isotope. This compound is a critical tool for advanced metabolic research, enabling precise tracking and quantification of glucose uptake and glycolytic flux in biological systems via techniques like NMR spectroscopy and mass spectrometry. It is essential for researchers and developers in pharmaceutical discovery, metabolic disease studies, and biochemistry who require high-fidelity isotopic tracers for accurate pathway analysis.

Application

• Metabolic Flux Analysis (MFA): Used as a 13C-labeled tracer to map and quantify intracellular metabolic pathways in cell cultures, tissues, and microorganisms.
• Drug Discovery & Development: Employed in preclinical studies to investigate the effects of novel therapeutic compounds on glucose metabolism and energy homeostasis.
• Cancer Research: Applied to study the Warburg effect and altered glycolytic metabolism in various cancer cell lines and tumor models.
• Neurological Research: Utilized in brain metabolism studies to understand energy utilization in neurons and glial cells under normal and pathological conditions.
• Diabetes and Metabolic Disorder Research: Serves as a key reagent for elucidating insulin resistance, glucose intolerance, and other dysfunctions in carbohydrate metabolism.
• Stable Isotope Labeling: Acts as a building block for the synthesis of more complex 13C-labeled glycans, nucleotides, or other bioactive molecules.
• Biomarker Discovery: Facilitates the identification and validation of metabolic biomarkers through precise isotopic enrichment patterns.

Basic Information

Product Name	2-Deoxy-D-[1-13C]Arabino-Hexose
CAS No.	201612-55-7
Molecular Formula	C513CH12O5
Molecular Weight	165.15 g/mol (for 13C1 isotopologue)
Synonyms	2-Deoxy-D-[1-13C]glucose; 2-Deoxy-D-[1-13C]aldohexose; [1-13C]-2-Deoxy-D-glucose; 1-13C-2-Deoxy-D-arabino-hexose; 2-Deoxy-D-glucose-1-13C; 2-DG-1-13C; Isotopic Labeled 2-Deoxyglucose; 13C1-2-Deoxy-D-glucose
EINECS	Contact for details

Quality Control

Every batch of 2-Deoxy-D-[1-13C]Arabino-Hexose is manufactured and analyzed under strict quality systems to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research. Our products undergo rigorous quality testing, including spectroscopic and chromatographic methods. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and specific analytical results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.