Description

1,2-Distearoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt) is a high-purity, synthetic phospholipid, specifically a phosphatidylglycerol (PG) derivative with saturated stearoyl chains. This compound is a critical building block for creating advanced lipid-based delivery systems, offering superior stability and formulation control. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced cosmetics industries developing liposomes, lipid nanoparticles (LNPs), and other bilayer structures for drug delivery, vaccine development, and targeted skincare.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key anionic lipid component for constructing stable, uniform vesicles for encapsulation and delivery of active pharmaceutical ingredients (APIs), mRNA vaccines, and genetic material.
• Drug Delivery Systems: Used to create stealth liposomes and targeted delivery vehicles to improve drug solubility, bioavailability, and to reduce systemic side effects.
• Biomimetic Membrane Research: Serves as a standard or model lipid for studying membrane biophysics, protein-lipid interactions, and cellular processes in vitro.
• Cosmetic & Dermal Applications: Incorporated into high-performance skincare formulations such as nanosomes and niosomes for enhanced penetration and stabilization of vitamins, antioxidants, and other actives.
• Diagnostic Reagents: Utilized in the development of diagnostic assays and kits that require precise membrane environments or liposomal signal amplification.
• Pulmonary Surfactant Research: Investigated as a component in synthetic lung surfactant formulations for respiratory distress syndrome research.

Basic Information

Product Name	1,2-Distearoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt)
CAS No.	200880-42-8
Molecular Formula	C42H82NaO10P
Molecular Weight	801.06 g/mol
Synonyms	DSPG-Na; 1,2-Distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt; 1,2-Di-O-octadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt; Phosphatidylglycerol (18:0/18:0) sodium salt; PG(18:0/18:0) sodium salt; DSPG Sodium Salt; 1,2-Distearoylphosphatidylglycerol sodium salt; Sodium 1,2-distearoyl-sn-glycero-3-phospho-(1'-glycerol)
EINECS	Contact for details

Quality Control

Our 1,2-Distearoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, TLC for identity and impurity profiling, and NMR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your critical research and GMP-grade formulation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Area Percent)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines
Phase Transition Temperature (DSC)	Contact for details
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.