Description

Roridin H is a potent macrocyclic trichothecene mycotoxin, a secondary metabolite produced by certain fungi. This compound is of significant interest in biochemical and pharmaceutical research due to its potent biological activity, particularly as a protein synthesis inhibitor. It serves as a critical reference standard and research tool for scientists in toxicology, mycology, and drug discovery. Key applications include its use in analytical method development, toxicity studies, and as a biochemical probe to investigate cellular mechanisms.

Application

• Analytical Reference Standard: Primary use as a certified standard for the accurate quantification and identification of trichothecene mycotoxins in food, feed, and environmental samples via HPLC, LC-MS/MS, and GC-MS.
• Biochemical Research: Employed as a potent inhibitor of eukaryotic protein synthesis to study ribosome function, stress responses, and apoptosis in cell biology and molecular biology experiments.
• Toxicology Studies: Used in in vitro and in vivo research to investigate the mechanisms of mycotoxin toxicity, establish dose-response relationships, and evaluate detoxification pathways.
• Mycological Research: Serves as a marker compound for studying the metabolism and pathogenicity of Stachybotrys and other toxin-producing fungal species.
• Pharmaceutical Development: Investigated for its potential in developing targeted therapies, leveraging its cytotoxic properties in controlled applications, such as antibody-drug conjugates (ADC) research.
• Quality Control & Safety Testing: Essential for laboratories developing and validating methods to ensure regulatory compliance and safety in the agriculture and food production industries.

Basic Information

Product Name	Roridin H
CAS No.	29953-50-2
Molecular Formula	C29H40O9
Molecular Weight	532.62 g/mol
Synonyms	Roridin H; Verrucarin J; 12',13'-Epoxy-3α,4β,15-triacetoxy-12',13'-dihydroxytrichothec-9-ene; (3α,4β)-3,4,15-Tris(acetyloxy)-12,13-epoxytrichothec-9-en-7,8-diol 7,8-diacetate; Trichothec-9-ene-3,4,7,8,15-pentaol, 12,13-epoxy-, 3,4,7,8,15-pentaacetate, (3α,4β,7α,8α)-; Satratoxin H analogue
EINECS	Contact for details

Quality Control

Every batch of Roridin H CAS NO 29953-50-2 is produced and handled under strict quality management protocols. Our products undergo rigorous identity, purity, and stability testing using advanced analytical techniques including HPLC, LC-MS, and NMR to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing batch-specific results for assay, purity, and related substances, is provided with each shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Research Grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.