Description

Parthenolide is a naturally occurring sesquiterpene lactone, a key bioactive compound primarily extracted from the medicinal herb Feverfew (*Tanacetum parthenium*). This compound matters for its significant and well-documented biological activity, particularly as a potent and selective inhibitor of the NF-κB signaling pathway, which plays a central role in inflammation and cell proliferation. It is a critical raw material for researchers in pharmaceutical development, nutraceutical formulation, and academic institutions focused on oncology, immunology, and anti-inflammatory therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a lead compound and reference standard in drug discovery programs targeting cancer, inflammatory diseases, and neurological disorders.
• Nutraceutical & Dietary Supplement Formulation: Used as a standardized active ingredient in high-grade Feverfew extracts for migraine prophylaxis and general anti-inflammatory support.
• Biochemical & Cell Biology Research: A vital tool compound for studying NF-κB pathway dynamics, apoptosis induction, and cellular stress responses in vitro.
• Reference Standard & Analytical Testing: Employed as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods to quantify parthenolide content in raw materials and finished products.
• Cosmeceutical Applications: Investigated for use in topical formulations aimed at soothing skin irritation and modulating inflammatory skin conditions due to its potent bioactivity.

Basic Information

Product Name	Parthenolide
CAS No.	29552-41-8
Molecular Formula	C15H20O3
Molecular Weight	248.32 g/mol
Synonyms	(-)-Parthenolide; NSC 628435; Santamarin; 4,5-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12,8β-olide; 1(10),4(5)-Diepoxy-11(13)-germacradien-12,8β-olide; Feverfew Lactone; Tanacetin
EINECS	249-716-7

Quality Control

Our Parthenolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent specifications for research and production use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). For long-term stability, storing desiccated at -20°C is recommended. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% - 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.