Description

Glipizide is a potent second-generation sulfonylurea compound widely recognized for its role in the management of type 2 diabetes mellitus. Its primary value lies in its ability to stimulate insulin secretion from pancreatic β-cells, effectively helping to control blood glucose levels. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing oral anti-diabetic medications. We supply Glipizide CAS NO 29094-61-9 to the global market, ensuring consistent quality and reliable supply for critical healthcare applications.

Application

Glipizide is a cornerstone API in diabetes treatment, with its primary and related applications including:

• Oral Anti-diabetic Drug Formulation: The principal use as the active ingredient in immediate-release and extended-release tablet formulations for type 2 diabetes.
• Combination Therapy Development: Used in fixed-dose combination drugs alongside other anti-diabetic agents like metformin for enhanced therapeutic effect.
• Pharmaceutical Research & Development: Serves as a reference standard and key material in R&D for novel drug delivery systems and new diabetes treatments.
• Generic Drug Manufacturing: A critical component for companies producing bioequivalent generic versions of branded glipizide medications.
• Clinical Trial Material: Supplied as GMP-grade material for use in clinical studies evaluating diabetes therapies.

Basic Information

Product Name	Glipizide
CAS No.	29094-61-9
Molecular Formula	C21H27N5O4S
Molecular Weight	445.54 g/mol
Synonyms	1-Cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea; Glipizida (Spanish, Italian); Glipizidum (Latin); Glydiazinamide; K4024; CP 28720; Gilbenese; Glibenese; Minodiab; Glucotrol; Glucotrol XL
EINECS	249-427-6

Quality Control

Our Glipizide is manufactured and tested to meet the highest pharmacopeial standards. Quality is assured through a rigorous, multi-stage analytical process in compliance with current Good Manufacturing Practices (cGMP). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material that conforms to USP, EP, and JP monographs, ensuring global regulatory acceptance for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and should be stored in a cool, dry place. Recommended storage temperature is between 15°C and 25°C. The container must be kept tightly sealed in a dry environment to prevent absorption of moisture, which could affect stability and performance.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	NMT 0.5%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.