Description

[1,2,5-Trimethyl-5-(Morpholin-4-Ylmethyl)-4-Phenyl-4-Piperidyl] Propanoate Dihydrochloride is a high-purity, complex organic salt with significant pharmacological research interest. This compound matters as a critical intermediate or reference standard in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry require this material for synthesis, analytical method development, and biological screening.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential therapeutic agents, especially in opioid receptor research.
• Reference Standard: Used in analytical laboratories for method validation, quality control, and impurity profiling via HPLC, LC-MS, or NMR.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Process Development: Employed in scaling up synthetic routes from milligram to kilogram scale under current Good Manufacturing Practices (cGMP).
• Academic Studies: Utilized in university and institutional research for investigating pharmacological mechanisms and metabolic pathways.
• Regulatory Submissions: Acts as a characterized starting material or impurity standard in drug master files (DMFs) and regulatory dossiers for agencies like the FDA and EMA.

Basic Information

Product Name	[1,2,5-Trimethyl-5-(Morpholin-4-Ylmethyl)-4-Phenyl-4-Piperidyl] Propanoate Dihydrochloride
CAS No.	28867-24-5
Molecular Formula	C24H39Cl2N2O3
Molecular Weight	474.48 g/mol
Synonyms	1,2,5-Trimethyl-5-(morpholin-4-ylmethyl)-4-phenyl-4-piperidinol propionate dihydrochloride; Propanoic acid, 1,2,5-trimethyl-5-(4-morpholinylmethyl)-4-phenyl-4-piperidinyl ester, dihydrochloride; 4-Piperidinol, 1,2,5-trimethyl-5-(4-morpholinylmethyl)-4-phenyl-, propanoate (ester), dihydrochloride; Loperamide Impurity G (Dihydrochloride); Loperamide Related Compound G; 1,2,5-Trimethyl-4-phenyl-4-piperidyl propionate derivative
EINECS	Contact for details

Quality Control

Our [1,2,5-Trimethyl-5-(Morpholin-4-Ylmethyl)-4-Phenyl-4-Piperidyl] Propanoate Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.