Description

3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-Diol is a high-purity polyethylene glycol (PEG) derivative, specifically a PEG 1000 diol, valued for its precise molecular weight and consistent terminal hydroxyl functionality. This compound is essential as a versatile building block and hydrophilic spacer in advanced chemical synthesis and material science. It is primarily needed by manufacturers in the pharmaceutical, bioconjugation, specialty polymer, and personal care industries for creating functionalized polymers, drug delivery systems, and high-performance surfactants.

Application

• Pharmaceutical Intermediate: Used as a linker or spacer in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and PEGylated therapeutic proteins to enhance solubility and circulation time.
• Polymer Chemistry: Serves as a macrodiol initiator or chain extender for synthesizing biodegradable polyesters, polyurethanes, and hydrogels with tailored properties.
• Surface Modification: Employed to create non-fouling, biocompatible coatings on medical devices, nanoparticles, and diagnostic surfaces.
• Cosmetic & Personal Care: Acts as a humectant, emulsifier, and viscosity modifier in high-end skincare and haircare formulations.
• Chemical Research: A key reagent in organic synthesis for introducing hydrophilic polyether segments into novel molecules and materials.
• Lubricants & Functional Fluids: Used as a base or additive in specialty lubricants and heat transfer fluids requiring high thermal stability and low toxicity.

Basic Information

Product Name	3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-Diol
CAS No.	28821-35-4
Molecular Formula	C44H90O46
Molecular Weight	~1066.10 g/mol
Synonyms	PEG 1000 Diol; Polyethylene Glycol 1000 Diol; α,ω-Dihydroxypoly(oxy-1,2-ethanediyl); Poly(oxy-1,2-ethanediyl), α-hydro-ω-hydroxy- (22-24 EO); 1,44-Dihydroxytetratetracontatetraoxa-3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaoxatetratetracontane; Poly(ethylene oxide) diol (MW ~1000); Polyoxyethylene diol (1000); HO-PEG1000-OH
EINECS	Contact for details

Quality Control

Our 3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-Diol is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, hydroxyl value, polydispersity, and moisture content. We support compliance with cGMP, ISO, and REACH standards, and specifications can be tailored to meet specific pharmacopeial (e.g., USP/NF, Ph. Eur.) or industrial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (by Titration)	≥ 95.0%
Hydroxyl Value	105 - 115 mg KOH/g
Average Molecular Weight (GPC)	950 - 1050 Da
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.